For our engineered protein nanoparticles to successfully encapsulate the therapeutic cargo, it must be recognized by the core structure. The core signaling sequences are naturally too large. Their excessive size reduces control over the encapsulation process, introduces risks, and limits cargo capacity. We have engineered the regulatory regions, reducing them to the absolute minimum required for efficient encapsulation—approximately 10-15% of their original size.
This optimization enhances:
✅ Encapsulation precision – Ensuring cargo is efficiently packaged within the nanoparticle.
✅ Safety – Minimizing uncontrolled interactions and associated risks.
✅ Cargo capacity – Increasing the space available for the therapeutic molecule.
Our design is inherently flexible. We have developed genetic control sequences that flank the cargo, allowing our nanoparticles to encapsulate a broad range of therapeutic molecules, including:
Once inside the target cell, the therapeutic cargo needs to function effectively. To ensure this, we have developed genetic sequences that:
✅ Guide cargo expression within the cell.
✅ Enable temporal control over cargo activity, allowing us to program the duration of its expression.
With this advanced level of control, we are not only delivering therapeutic molecules but also defining how and when they function within the body—unlocking new possibilities for precision medicine.
